M-Audio Radium 49 is an "end of life" legacy product, and there are no official drivers for modern versions of macOS (Ventura, Sonoma, or Sequoia).
Manually draw a connection between the new device and your USB interface icon. m-audio radium 49 driver mac
Recommendation: Use it as a simple MIDI keyboard or recycle it. For serious production, invest in a 2020+ controller. M-Audio Radium 49 is an "end of life"
suggest using an open-source driver project on GitHub (e.g., midisport-macos What works: The keys usually send Note On/Off data
The last known working drivers for older Intel Macs include:
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