Resident Evil 5 (RE5) remains a beloved co-op classic, but its Steam version has a notorious reputation. Almost fifteen years after its initial release, players are still wrestling with the ghost of Games for Windows Live (GFWL) , launch crashes, infinite loading screens, and the dreaded "Fatal Application Exit" error.
Specific Fixes
The most critical fix for modern systems is often cited as the or the comprehensive Quality of Life Fixes available on the Resident Evil 5 Steam Community Guides Bypassing GFWL Artifacts: re5 steam fix
Before applying the fix, it helps to understand the enemy. Capcom released a patch in 2016 to remove GFWL, but the migration was sloppy. The current Steam build suffers from: The Ultimate RE5 Steam Fix: Solving Crashes, GFWL
Native Split-Screen: Restores the ability to play with a friend on one PC (one on keyboard/mouse, one on controller, or two controllers). Press Windows Key + R , type sysdm
Windows Key + R, type sysdm.cpl, and hit Enter.\Steam\steamapps\common\Resident Evil 5\RE5DX9.exe and RE5DX10.exe.