It sounds like you're looking for guidance related to a specific software version ("Shadow Defender 140680") and its potential use with IIS on a Windows Server environment (noting that "Windows Server 2021" doesn't officially exist; the latest are Server 2019, 2022, and 2025).
Exclusion Lists: Users can specify files or folders that should remain "real" and persist through reboots even while in Shadow Mode. shadow defender 140680 download iis windows server 2021
The official website for Shadow Defender is shadowdefender.com. As with any software: It sounds like you're looking for guidance related