If you are trying to get Xilinx ISE 14.7 running on Windows 10, you should be aware that the original software was designed for older versions of Windows and often fails to run directly on modern hardware.
For Digilent Boards (Nexys 2, Nexys 3, Basys 2): xilinx ise 14.7 windows 10
If you cannot open the License Manager:
If you are struggling, run through this checklist: If you are trying to get Xilinx ISE 14